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关 键 词:蓖麻凝集素
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发布时间:2010-10-19
Since the 1880’s, it has been known that extracts from certain plants could agglutinate red blood cells. In the 1940’s, agglutinins were discovered which could “select” types of cells based on their blood group activities. Although “lectin” was originally coined to define agglutinins which could discriminate among types of red blood cells, today the term is used more generally and includes sugar-binding proteins from many sources regardless of their ability to agglutinate cells. Lectins have been found in plants, viruses, microorganisms and animals, but despite their ubiquity, their function in nature is unclear. Although lectins share the common property of binding to defined sugar structures, their roles in various organisms are not likely to be the same. Most lectins studied to date are multimeric, consisting of non-covalently associated subunits. A lectin may contain two or more of the same subunit, such as Con A, or different subunits, such as Phaseolus vulgaris agglutinin. It is this multimeric structure which gives lectins their ability to agglutinate cells or form precipitates with glycoconjugates in a manner similar to antigen-antibody interactions. Although most lectins can agglutinate some cell type, cellular agglutination is not a prerequisite. Some lectins can bind to cells and not cause agglutination, such as succinylated Con A, or the lectin may not bind to cells at all. The latter property may be a consequence of the structure of the lectin or the absence of a suitable receptor oligosaccharide on the cell surface. Since agglutination of cells is the assay most generally employed to measure lectins, many non-agglutinating lectins may exist in nature but have not been easily detected. 产品名称 货号 规格 Lectin 1.Agarose bound Lectins Agarose bound* Aleuria Aurantia Lectin (AAL) AL-1393 2 ml Agarose bound* Concanavalin A (Con A) AL-1003 10ml/100ml 2.Antibodies to Lectins Anti-Concanavalin A AS-2004 1 mg Anti-Dolichos biflorus agglutinin AS-2034 1 mg 3.Biotinylated Anti-Lectins Biotinylated Anti-Peanut agglutinin BA-0074 0.5 mg Biotinylated Anti-Phaseolus Vulgaris aggutinin (E+L) BA-0224 0.5 mg 4.Biotinylated Lectins Biotinylated Aleuria Aurantia Lectin (AAL) B-1395 1 mg Biotinylated Amaranthus Caudatus Lectin B-1255 2 mg 5.Lectin Screening Kits Biotinylated Lectin Kit I BK-1000 1 kit Biotinylated Lectin Kit II BK-2000 1 kit 6.Lectins and Lectin Conjugates Agarose bound* Aleuria Aurantia Lectin (AAL) AL-1393 2 ml Alkaline Phosphatase Aleuria aurantia lectin (AAL) MB-4100 150 ug 7.Unconjugated Maclura Pomifera Lectin (MPL) Biotinylated Narcissus Pseudonarcissus Lectin (NPL, NPA) B-1375 2 mg Unconjugated Narcissus Pseudonarcissus Lectin (NPL, NPA) L-1370 5 mg 8.糖类 a-methyl glucoside S-9006 5 ml a-methyl mannoside S-9005 5 ml galactose S-9003 5 ml lactose S-9004 5 ml L-fucose S-9007 5 ml N-acetylgalactosamine S-9001 5 ml N-acetylglucosamine S-9002 5 ml N-acetylneuraminic acid (sialic acid) S-9008 5 ml Chitin Hydrolysate SP-0090 10 ml